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Title: R2d2 Drives Selfish Sweeps in the House Mouse
Authors: John P. Didion
Andrew P. Morgan
Liran Yadgary
Timothy A. Bell
Rachel C. McMullan
Lydia Ortiz De Solorzano
Janice Britton-Davidian
Carol J. Bult
Karl J. Campbell
Riccardo Castiglia
Yung Hao Ching
Amanda J. Chunco
James J. Crowley
Elissa J. Chesler
Daniel W. Förster
John E. French
Sofia I. Gabriel
Daniel M. Gatti
Theodore Garland
Eva B. Giagia-Athanasopoulou
Mabel D. Giménez
Sofia A. Grize
Islam Gündüz
Andrew Holmes
Heidi C. Hauffe
Jeremy S. Herman
James M. Holt
Kunjie Hua
Wesley J. Jolley
Anna K. Lindholm
María J. López-Fuster
George Mitsainas
Maria Da Luz Mathias
Leonard McMillan
Maria Da Graça Morgado Ramalhinho
Barbara Rehermann
Stephan P. Rosshart
Jeremy B. Searle
Meng Shin Shiao
Emanuela Solano
Karen L. Svenson
Patricia Thomas-Laemont
David W. Threadgill
Jacint Ventura
George M. Weinstock
Daniel Pomp
Gary A. Churchill
Fernando Pardo Manuel De Villena
The University of North Carolina at Chapel Hill
Université de Montpellier
Jackson Laboratory
Island Conservation
University of Queensland
Università degli Studi di Roma La Sapienza
Tzu Chi University
Elon University
Leibniz-Institut fur Zoo- und Wildtierforschung
National Institute of Environmental Health Sciences
Faculdade de Ciências, Universidade de Lisboa
University of California, Riverside
Panepistimion Patron
Instituto de Biologia Subtropical
University of Zurich
Ondokuz Mayis University Faculty of Science and Arts
National Institute on Alcohol Abuse and Alcoholism
Istituto Agrario San Michele all'Adige
National Museums of Scotland
Island Conservation
Universitat de Barcelona
National Institute of Diabetes and Digestive and Kidney Diseases
Cornell University
Mahidol University
Texas A and M University
Universitat Autònoma de Barcelona
Jackson Laboratory for Genomic Medicine
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 2-Jun-2016
Citation: Molecular Biology and Evolution. Vol.33, No.6 (2016), 1381-1395
Abstract: © 2016 The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. Population-level sequencing data have enabled discoveries of selective sweeps associated with genes involved in recent adaptations in many species. In contrast, much debate but little evidence addresses whether "selfish" genes are capable of fixation - thereby leaving signatures identical to classical selective sweeps - despite being neutral or deleterious to organismal fitness. We previously described R2d2, a large copy-number variant that causes nonrandom segregation of mouse Chromosome 2 in females due to meiotic drive. Here we show population-genetic data consistent with a selfish sweep driven by alleles of R2d2 with high copy number (R2d2HC) in natural populations. We replicate this finding in multiple closed breeding populations from six outbred backgrounds segregating for R2d2 alleles. We find that R2d2HC rapidly increases in frequency, and in most cases becomes fixed in significantly fewer generations than can be explained by genetic drift. R2d2HC is also associated with significantly reduced litter sizes in heterozygous mothers, making it a true selfish allele. Our data provide direct evidence of populations actively undergoing selfish sweeps, and demonstrate that meiotic drive can rapidly alter the genomic landscape in favor of mutations with neutral or even negative effects on overall Darwinian fitness. Further study will reveal the incidence of selfish sweeps, and will elucidate the relative contributions of selfish genes, adaptation and genetic drift to evolution.
ISSN: 15371719
Appears in Collections:Scopus 2016-2017

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