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Title: Evaluation of a portable microchip electrophoresis fluorescence detection system for the analysis of amino acid neurotransmitters in brain dialysis samples
Authors: Nathan J. Oborny
Elton E.Melo Costa
Leena Suntornsuk
Fabiane C. Abreu
Susan M. Lunte
University of Kansas
Universidade Federal de Alagoas
Mahidol University
Keywords: Chemistry
Issue Date: 1-Jan-2016
Citation: Analytical Sciences. Vol.32, No.1 (2016), 35-40
Abstract: © 2016 The Japan Society for Analytical Chemistry. A portable fluorescence detection system for use with microchip electrophoresis was developed and compared to a benchtop system. Using this system, six neuroactive amines commonly found in brain dialysate (arginine, citrulline, taurine, histamine, glutamate, and aspartate) were derivatized offline with naphthalene-2,3-dicarboxaldehyde/cyanide, separated electrophoretically, and detected by fluorescence. The limits of detection for the analytes of interest were 50 - 250 nM for the benchtop system and 250 nM - 1.3 μM for the portable system, both of which were adequate for most analyte detection in brain microdialysis samples. The portable system was then demonstrated for the detection of the same six amines in a rat brain microdialysis sample.
ISSN: 13482246
Appears in Collections:Scopus 2016-2017

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