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Title: Cellular automata simulation of signal transduction and calcium dynamics with healthy and faulty receptor trafficking
Authors: Chontita Rattanakul
Yongwimon Lenbury
Mahidol University
Commission on Higher Education
Keywords: Computer Science;Engineering
Issue Date: 13-Jun-2016
Citation: 10th Annual International Systems Conference, SysCon 2016 - Proceedings. (2016)
Abstract: © 2016 IEEE. The signal transduction process is one by which an external signal is detected by the cell and converted into cellular responsive actions leading to changes in secondary messengers, such as cAMP (cyclic adenosine monophosphate) or intracellular calcium. Calcium is an important second messenger and has been the subject of numerous experimental investigations and dynamic studies in intracellular signaling. Defects in the signaling process involving the calcium-sensing receptors can lead to faulty re-adjustments of circulating calcium level. Dimerization process has also been proposed to play an important role in the efficiency of the receptor responses. Here, we construct and simulate a Monte Carlo cellular automata model coupled with a system of difference equations to model receptor binding, trafficking, and dimerization triggered by an agonist, while keeping track of the concentration of cytosolic free calcium by using a system of difference equations.
Appears in Collections:Scopus 2016-2017

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