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dc.contributor.authorChontita Rattanakulen_US
dc.contributor.authorYongwimon Lenburyen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherCommission on Higher Educationen_US
dc.identifier.citation10th Annual International Systems Conference, SysCon 2016 - Proceedings. (2016)en_US
dc.description.abstract© 2016 IEEE. The signal transduction process is one by which an external signal is detected by the cell and converted into cellular responsive actions leading to changes in secondary messengers, such as cAMP (cyclic adenosine monophosphate) or intracellular calcium. Calcium is an important second messenger and has been the subject of numerous experimental investigations and dynamic studies in intracellular signaling. Defects in the signaling process involving the calcium-sensing receptors can lead to faulty re-adjustments of circulating calcium level. Dimerization process has also been proposed to play an important role in the efficiency of the receptor responses. Here, we construct and simulate a Monte Carlo cellular automata model coupled with a system of difference equations to model receptor binding, trafficking, and dimerization triggered by an agonist, while keeping track of the concentration of cytosolic free calcium by using a system of difference equations.en_US
dc.rightsMahidol Universityen_US
dc.subjectComputer Scienceen_US
dc.titleCellular automata simulation of signal transduction and calcium dynamics with healthy and faulty receptor traffickingen_US
dc.typeConference Paperen_US
Appears in Collections:Scopus 2016-2017

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