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Title: Molecular assays for antimalarial drug resistance surveillance: A target product profile
Authors: Christian Nsanzabana
Frederic Ariey
Hans Peter Beck
Xavier C. Ding
Edwin Kamau
Sanjeev Krishna
Eric Legrand
Naomi Lucchi
Olivo Miotto
Sidsel Nag
Harald Noedl
Cally Roper
Philip J. Rosenthal
Henk D.F.H. Schallig
Steve M. Taylor
Sarah K. Volkman
Iveth J. Gonzalez
Duke University Medical Center
Medizinische Universitat Wien, Zentrum für Pathophysiologie, Infektiologie und Immunologie
Foundation for Innovative New Diagnostics, Switzerland
Harvard School of Public Health
London School of Hygiene & Tropical Medicine
Københavns Universitet
St George's University of London
Universite Paris Descartes
University of Oxford
University of California, San Francisco
Universitat Basel
Swiss Tropical and Public Health Institute (Swiss TPH)
Centers for Disease Control and Prevention
Hopital Cochin AP-HP
Copenhagen University Hospital
Walter Reed Army Institute of Research
Mahidol University
United States Army
Wellcome Sanger Institute
University of Amsterdam
Institut Pasteur, Paris
Broad Institute
Simmons University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Sep-2018
Citation: PLoS ONE. Vol.13, No.9 (2018)
Abstract: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance following treatment with artemisinin derivatives has now spread in the Greater Mekong Sub region and may emerge or spread to other malaria endemic regions. This spread is of great concern for malaria control programmes, as no alternatives to artemisinin-based combination therapies are expected to be available in the near future. There is a need to strengthen surveillance systems for early detection and response to the antimalarial drug resistance threat. Current surveillance is mainly done through therapeutic efficacy studies; however these studies are complex and both time- and resource-intensive. For multiple common antimalarials, parasite drug resistance has been correlated with specific genetic mutations, and the molecular markers associated with antimalarial drug resistance offer a simple and powerful tool to monitor the emergence and spread of resistant parasites. Different techniques to analyse molecular markers associated with antimalarial drug resistance are available, each with advantages and disadvantages. However, procedures are not adequately harmonized to facilitate comparisons between sites. Here we describe the target product profiles for tests to analyse molecular markers associated with antimalarial drug resistance, discuss how use of current techniques can be standardised, and identify the requirements for an ideal product that would allow malaria endemic countries to provide useful spatial and temporal information on the spread of resistance.
ISSN: 19326203
Appears in Collections:Scopus 2018

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