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Title: Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration
Authors: Matthias W. Lorenz
Lu Gao
Kathrin Ziegelbauer
Giuseppe Danilo Norata
Jean Philippe Empana
Irene Schmidtmann
Hung Ju Lin
Stela McLachlan
Lena Bokemark
Kimmo Ronkainen
Mauro Amato
Ulf Schminke
Sathanur R. Srinivasan
Lars Lind
Shuhei Okazaki
Coen D.A. Stehouwer
Peter Willeit
Joseph F. Polak
Helmuth Steinmetz
Dirk Sander
Holger Poppert
Moise Desvarieux
M. Arfan Ikram
Stein Harald Johnsen
Daniel Staub
Cesare R. Sirtori
Bernhard Iglseder
Oscar Beloqui
Gunnar Engström
Alfonso Friera
Francesco Rozza
Wuxiang Xie
Grace Parraga
Liliana Grigore
Matthieu Plichart
Stefan Blankenberg
Ta Chen Su
Caroline Schmidt
Tomi Pekka Tuomainen
Fabrizio Veglia
Henry Völzke
Giel Nijpels
Johann Willeit
Ralph L. Sacco
Oscar H. Franco
Heiko Uthoff
Bo Hedblad
Carmen Suarez
Raffaele Izzo
Dong Zhao
Thapat Wannarong
Alberico Catapano
Pierre Ducimetiere
Christine Espinola-Klein
Kuo Liong Chien
Jackie F. Price
Göran Bergström
Jussi Kauhanen
Elena Tremoli
Marcus Dörr
Gerald Berenson
Kazuo Kitagawa
Jacqueline M. Dekker
Stefan Kiechl
Matthias Sitzer
Horst Bickel
Tatjana Rundek
Albert Hofman
Ellisiv B. Mathiesen
Samuela Castelnuovo
Manuel F. Landecho
Maria Rosvall
Rafael Gabriel
Nicola de Luca
Jing Liu
Damiano Baldassarre
Maryam Kavousi
Eric de Groot
Michiel L. Bots
David N. Yanez
Simon G. Thompson
Deutsches Zentrum für Herz-Kreislauf-Forschung e. V.
University Hospital of North Norway
IRCCS Multimedica
Itä-Suomen yliopisto
IRCCS Centro Cardiologico Monzino
Beijing Anzhen Hospital
National Taiwan University Hospital
Cardiovascular Research Institute Maastricht
Sahlgrenska University Hospital, Wallenberg Laboratory
University Medical Center Utrecht
Erasmus University Medical Center
Johannes Gutenberg Universität Mainz
University of Cambridge
Università degli Studi di Milano
Robarts Research Institute
Lunds Universitet
Universite Paris Descartes
Universitätsspital Basel
Columbia University Medical Center
University of Edinburgh
Tokyo Women's Medical University
Klinikum Herford
Hospital Universitario de la Princesa
Universitätsklinikum Greifswald der Ernst-Moritz-Arndt-Universität Greifswald
University of Miami Leonard M. Miller School of Medicine
UiT The Arctic University of Norway
Tulane University School of Public Health and Tropical Medicine
Clinica Universitaria de Navarra
Technical University of Munich
Università degli Studi di Napoli Federico II
Tufts University School of Medicine
Ospedale Niguarda, Milan
University of Washington, Seattle
Tulane University School of Medicine
Osaka University Faculty of Medicine
EMGO Institute for Health and Care Research
Groupe Hospitalier Broca AP-HP
Faculty of Medicine, Siriraj Hospital, Mahidol University
University of Cambridge, Institute of Public Health
Medizinische Universitat Innsbruck
Goethe-Universität Frankfurt am Main
National Taiwan University
Universitätsklinikum Hamburg-Eppendorf und Medizinische Fakultät
Uppsala Universitet
Amsterdam UMC - Vrije Universiteit Amsterdam
Instituto de Salud Carlos III
Amsterdam UMC - University of Amsterdam
University Paris_Sud Xi
Benedictus Hospital Tutzing & Feldafing
Parcelsus Medical University
Imagelabonline & Cardiovascular
SHIP/Clinical-Epidemiological Research
University Medicine Greifswald
Bassini Hospital
Institut für Medizinische Biometrie
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Apr-2018
Citation: PLoS ONE. Vol.13, No.4 (2018)
Abstract: © 2018 Lorenz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Aims Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95–1.02) in group A, 0.98 (0.93–1.04) in group B, and 0.95 (0.89–1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07–1.23) in group A, 1.13 (1.05–1.22) in group B, and 1.12 (1.05–1.20) in group C. Conclusions We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.
ISSN: 19326203
Appears in Collections:Scopus 2018

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