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Title: Anti-HIV and cytotoxic biphenyls, benzophenones and xanthones from stems, leaves and twigs of Garcinia speciosa
Authors: Phanruethai Pailee
Chutima Kuhakarn
Chanyapat Sangsuwan
Sakchai Hongthong
Pawinee Piyachaturawat
Kanoknetr Suksen
Surawat Jariyawat
Radeekorn Akkarawongsapat
Jitra Limthongkul
Chanita Napaswad
Palangpon Kongsaeree
Samran Prabpai
Thaworn Jaipetch
Manat Pohmakotr
Patoomratana Tuchinda
Vichai Reutrakul
Suan Sunandha Rajabhat University
Chulabhorn Research Institute
Mahidol University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Mar-2018
Citation: Phytochemistry. Vol.147, (2018), 68-79
Abstract: © 2017 Elsevier Ltd Eleven previously undescribed compounds, including four benzophenones (garciosones A−D), four xanthones (garciosones E−H) and three biphenyls (garciosines A−C), along with eighteen known compounds were isolated from the stems, leaves and twigs of Garcinia speciosa Wall. (Clusiaceae). Their structures were established by extensive spectroscopic analysis. For garciosines A−C, the structures were confirmed by single crystal X-ray diffraction analysis. Most of the isolated compounds were evaluated for their cytotoxic activity and anti-HIV-1 activity using the syncytium inhibition assay and HIV-1 reverse transcriptase (RT) assay. The known compounds, 4,6,3′,4′-tetrahydroxy-2-methoxybenzophenone and macluraxanthone, displayed significant cytotoxic activity with the ED50 in the range of 1.85–11.76 μM. 1,5-Dihydroxyxanthone exhibited the most potent anti-HIV activity against syncytium formation with EC50 < 17.13 μM (SI > 25.28) and 2-(3,3-dimethylallyl)-1,3,7-trihydroxyxanthone was the most active compound in the HIV-1 reverse transcriptase assay with IC50 value of 58.24 μM. Structure-activity relationship of some isolated compounds were also discussed.
ISSN: 00319422
Appears in Collections:Scopus 2018

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