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Title: Anti-HIV 1 activity of xanthones from the bark of mammea harmandii
Authors: Ponsiri Liangsakul
Chutima Kuhakarn
Sakchai Hongthong
Surawat Jariyawat
Kanoknetr Suksen
Radeekorn Akkarawongsapat
Jitra Limthongkul
Chanita Napaswad
Vichai Reutrakul
Kasetsart University, Kamphaeng Saen Campus
Mahidol University
Keywords: Agricultural and Biological Sciences;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2018
Citation: Natural Product Communications. Vol.13, No.1 (2018), 53-56
Abstract: © 2018 Natural Product Incorporation. All Rights Reserved. A new xanthone glycoside 1 together with four known flavonoid derivatives, astilbin (2), neoastilbin (3), isoastilbin (4), and epicatechin (5) were isolated from the ethyl acetate fraction partitioned from the methanol extract of the bark of Mammea harmandii. The chemical structures of all isolated compounds were established on the basis of their spectroscopic data. Compound 1 exhibited selective significant inhibitory activity in the anti-syncytium assay with an EC50 value of 11.44 M (SI = 14.03) while it was found inactive against HIV 1 reverse transcriptase as well as cytotoxic activity.
ISSN: 15559475
Appears in Collections:Scopus 2018

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