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Title: Anti-HIV activity of alkaloids from dasymaschalon echinatum
Authors: Samreang Bunteang
Waraporn Chanakul
Sakchai Hongthong
Chutima Kuhakarn
Watcharra Chintakovid
Natthapat Sungchawek
Radeekorn Akkarawongsapat
Jitra Limthongkul
Narong Nantasaen
Vichai Reutrakul
Thaworn Jaipetch
King Mongkut's University of Technology North Bangkok
Mahidol University
Ministry of Natural Resources and Environment
Keywords: Agricultural and Biological Sciences;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2018
Citation: Natural Product Communications. Vol.13, No.1 (2018), 29-32
Abstract: © 2018 Natural Product Incorporation. All Rights Reserved. Bioassay-guided fractionation of the aerial parts of Dasymaschalon echinatum led to the isolation of five known aristolactams; aristolactam AII (1), aristolactam BII (2), piperolactam A (3), piperolactam C (4), and goniopedaline (5), together with two aphorphine alkaloids; duguevalline (6) and noraristolodione (7) and two amide derivatives; asperphenamate (8), and N-benzoyl-L-phenylalaninol (9). Alkaloids 2 and 7 were isolated for the first time from the Dasymaschalon genus. The anti-HIV 1 reverse transcriptase (RT) activity of all isolated compounds was determined. Except for aristolactam BII (2), this is the first report of the anti-HIV 1-RT activity of compounds 1 and 3-9. Compounds 1, 3, 5, 6 and 8 showed weak anti-HIV 1-RT inhibitory activity with IC50 ranging from 112.74 to 225.55 M.
ISSN: 15559475
Appears in Collections:Scopus 2018

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