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Title: Coumarins and flavones from the fruit and root extracts of Micromelum integerrimum
Authors: Virayu Suthiphasilp
Wisanu Maneerat
Raymond J. Andersen
Stephen G. Pyne
Chatchai Muanprasat
Sawinee Seemakhan
Suparerk Borwornpinyo
Surat Laphookhieo
Mae Fah Luang University
Mahidol University
University of Wollongong
The University of British Columbia
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 1-Jan-2018
Citation: Natural Product Research. (2018)
Abstract: © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. A phytochemical investigation of the fruit and root extracts of Micromelum integerrimum resulted in the isolation and identification of a new compound, integerravone (1), together with 23 known compounds (2–24). Their structures were characterized by spectroscopic methods as well as comparisons made from the literature. Compounds 2, 3–15, 17–18 and 20–23 were evaluated for their cytotoxicities against the colon cancer cell line, HCT116. All of them were inactive at 50 µM. Most of the phenolic compounds were evaluated for their antioxidant activity using the DPPH assay. Compounds 14 and 22–24 showed antioxidant activity with IC50 values ranging from 24.83-135.05 µM.
ISSN: 14786427
Appears in Collections:Scopus 2018

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