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Title: Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy
Authors: Nicole L. Bertschi
Annemarie Voorberg-Van der Wel
Anne Marie Zeeman
Sven Schuierer
Florian Nigsch
Walter Carbone
Judith Knehr
Devendra K. Gupta
Sam O. Hofman
Nicole van der Werff
Ivonne Nieuwenhuis
Els Klooster
Bart W. Faber
Erika L. Flannery
Sebastian A. Mikolajczak
Vorada Chuenchob
Binesh Shrestha
Martin Beibel
Tewis Bouwmeester
Niwat Kangwanrangsan
Jetsumon Sattabongkot
Thierry T. Diagana
Clemens H.M. Kocken
Guglielmo Roma
Biomedical Primate Research Centre - Rijswijk
Mahidol University
Novartis International AG
Novartis Pharmaceuticals
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Neuroscience
Issue Date: 1-Dec-2018
Citation: eLife. Vol.7, (2018)
Abstract: © Bertschi et al. Relapses of Plasmodium dormant liver hypnozoites compromise malaria eradication efforts. New radical cure drugs are urgently needed, yet the vast gap in knowledge of hypnozoite biology impedes drug discovery. We previously unraveled the transcriptome of 6 to 7 day-old P. cynomolgi liver stages, highlighting pathways associated with hypnozoite dormancy (Voorberg-van der Wel et al., 2017). We now extend these findings by transcriptome profiling of 9 to 10 day-old liver stage parasites, thus revealing for the first time the maturation of the dormant stage over time. Although progression of dormancy leads to a 10-fold decrease in transcription and expression of only 840 genes, including genes associated with housekeeping functions, we show that pathways involved in quiescence, energy metabolism and maintenance of genome integrity remain the prevalent pathways active in mature hypnozoites.
ISSN: 2050084X
Appears in Collections:Scopus 2018

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