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Title: Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics
Authors: Sarah Auburn
Ernest D. Benavente
Olivo Miotto
Richard D. Pearson
Roberto Amato
Matthew J. Grigg
Bridget E. Barber
Timothy William
Irene Handayuni
Jutta Marfurt
Hidayat Trimarsanto
Rintis Noviyanti
Kanlaya Sriprawat
Francois Nosten
Susana Campino
Taane G. Clark
Nicholas M. Anstey
Dominic P. Kwiatkowski
Ric N. Price
Badan Pengkajian dan Penerapan Teknologi
Eijkman Institute for Molecular Biology
London School of Hygiene & Tropical Medicine
Menzies School of Health Research
Mahidol University
Nuffield Department of Clinical Medicine
Wellcome Sanger Institute
Li Ka Shing Centre for Health Information and Discovery
Jesselton Medical Centre
Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit
Queen Elizabeth Hospital
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Physics and Astronomy
Issue Date: 1-Dec-2018
Citation: Nature Communications. Vol.9, No.1 (2018)
Abstract: © 2018 The Author(s). The incidence of Plasmodium vivax infection has declined markedly in Malaysia over the past decade despite evidence of high-grade chloroquine resistance. Here we investigate the genetic changes in a P. vivax population approaching elimination in 51 isolates from Sabah, Malaysia and compare these with data from 104 isolates from Thailand and 104 isolates from Indonesia. Sabah displays extensive population structure, mirroring that previously seen with the emergence of artemisinin-resistant P. falciparum founder populations in Cambodia. Fifty-four percent of the Sabah isolates have identical genomes, consistent with a rapid clonal expansion. Across Sabah, there is a high prevalence of loci known to be associated with antimalarial drug resistance. Measures of differentiation between the three countries reveal several gene regions under putative selection in Sabah. Our findings highlight important factors pertinent to parasite resurgence and molecular cues that can be used to monitor low-endemic populations at the end stages of P. vivax elimination.
ISSN: 20411723
Appears in Collections:Scopus 2018

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