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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/44992
Title: Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages
Authors: Evelien M. Bunnik
Kate B. Cook
Nelle Varoquaux
Gayani Batugedara
Jacques Prudhomme
Anthony Cort
Lirong Shi
Chiara Andolina
Leila S. Ross
Declan Brady
David A. Fidock
Francois Nosten
Rita Tewari
Photini Sinnis
Ferhat Ay
Jean Philippe Vert
William Stafford Noble
Karine G. Le Roch
Département de Mathématiques et Applications
Institut Curie
Mines ParisTech
Columbia University in the City of New York
University of California, Riverside
Columbia University Medical Center
University of Oxford
University of California, Berkeley
University of Texas Health Science Center at San Antonio
University of Washington, Seattle
University of Nottingham
La Jolla Institute for Allergy and Immunology
Mahidol University
Johns Hopkins Bloomberg School of Public Health
Inserm
Berkeley Global Science Institute
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Physics and Astronomy
Issue Date: 1-Dec-2018
Citation: Nature Communications. Vol.9, No.1 (2018)
Abstract: © 2018 The Author(s). The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells. Here, we analyze genome organization in the P. falciparum and P. vivax transmission stages. Major changes occur in the localization and interactions of genes involved in pathogenesis and immune evasion, host cell invasion, sexual differentiation, and master regulation of gene expression. Furthermore, we observe reorganization of subtelomeric heterochromatin around genes involved in host cell remodeling. Depletion of heterochromatin protein 1 (PfHP1) resulted in loss of interactions between virulence genes, confirming that PfHP1 is essential for maintenance of the repressive center. Our results suggest that the three-dimensional genome structure of human malaria parasites is strongly connected with transcriptional activity of specific gene families throughout the life cycle.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047179219&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/44992
ISSN: 20411723
Appears in Collections:Scopus 2018

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