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Title: Oncoplastic Breast Consortium consensus conference on nipple-sparing mastectomy
Authors: Walter P. Weber
Martin Haug
Christian Kurzeder
Vesna Bjelic-Radisic
Rupert Koller
Roland Reitsamer
Florian Fitzal
Jorge Biazus
Fabricio Brenelli
Cicero Urban
Régis Resende Paulinelli
Jens Uwe Blohmer
Jörg Heil
Jürgen Hoffmann
Zoltan Matrai
Giuseppe Catanuto
Viviana Galimberti
Oreste Gentilini
Mitchel Barry
Tal Hadar
Tanir M. Allweis
Oded Olsha
Maria João Cardoso
Pedro F. Gouveia
Isabel T. Rubio
Jana de Boniface
Tor Svensjö
Susanne Bucher
Peter Dubsky
Jian Farhadi
Mathias K. Fehr
Ilario Fulco
Ursula Ganz-Blättler
Andreas Günthert
Yves Harder
Nik Hauser
Elisabeth A. Kappos
Michael Knauer
Julia Landin
Robert Mechera
Francesco Meani
Giacomo Montagna
Mathilde Ritter
Ramon Saccilotto
Fabienne D. Schwab
Daniel Steffens
Christoph Tausch
Jasmin Zeindler
Savas D. Soysal
Visnu Lohsiriwat
Tibor Kovacs
Anne Tansley
Lynda Wyld
Laszlo Romics
Mahmoud El-Tamer
Andrea L. Pusic
Virgilio Sacchini
Michael Gnant
New Victoria Hospital, Glasgow
Champalimaud Foundation
Universidade Positivo
Azienda Ospedaliera Cannizzaro
IRCCS San Raffaele Scientific Institute
Klinik St. Anna
Uniklinik Düsseldorf
Ente Ospedaliero Cantonale
Universidad de Navarra
Kaplan Medical Center Israel
Kantonsspital Luzern
Országos Onkológiai Intézet Budapest
Istituto Europeo di Oncologia
Universidade Estadual de Campinas
Universitätsspital Basel
Universität St. Gallen
Charité – Universitätsmedizin Berlin
Kristianstad Central Hospital
Universitat Basel
Centre Hospitalier Universitaire Vaudois
Universität Witten/Herdecke
Mater Misericordiae University Hospital
Brigham and Women's Hospital
Hospital de Clinicas de Porto Alegre
Karolinska Institutet
Medizinische Universitat Wien
Klinik Hirslanden
Faculty of Medicine, Siriraj Hospital, Mahidol University
Memorial Sloan-Kettering Cancer Center
Royal Liverpool and Broadgreen University Hospitals NHS Trust
Hebrew University of Jerusalem
Medizinische Universität Graz
Guy's and St Thomas' NHS Foundation Trust
Universitat Salzburg
University of Sheffield
Capio S:t Görans Sjukhus
Wiener Krakenanstaltenverbund
Breast Center Zürich
Breast Center St. Gallen
University of Heidelberg
Araújo Jorge Hospital
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Dec-2018
Citation: Breast Cancer Research and Treatment. Vol.172, No.3 (2018), 523-537
Abstract: © 2018, The Author(s). Purpose: Indications for nipple-sparing mastectomy (NSM) have broadened to include the risk reducing setting and locally advanced tumors, which resulted in a dramatic increase in the use of NSM. The Oncoplastic Breast Consortium consensus conference on NSM and immediate reconstruction was held to address a variety of questions in clinical practice and research based on published evidence and expert panel opinion. Methods: The panel consisted of 44 breast surgeons from 14 countries across four continents with a background in gynecology, general or reconstructive surgery and a practice dedicated to breast cancer, as well as a patient advocate. Panelists presented evidence summaries relating to each topic for debate during the in-person consensus conference. The iterative process in question development, voting, and wording of the recommendations followed the modified Delphi methodology. Results: Consensus recommendations were reached in 35, majority recommendations in 24, and no recommendations in the remaining 12 questions. The panel acknowledged the need for standardization of various aspects of NSM and immediate reconstruction. It endorsed several oncological contraindications to the preservation of the skin and nipple. Furthermore, it recommended inclusion of patients in prospective registries and routine assessment of patient-reported outcomes. Considerable heterogeneity in breast reconstruction practice became obvious during the conference. Conclusions: In case of conflicting or missing evidence to guide treatment, the consensus conference revealed substantial disagreement in expert panel opinion, which, among others, supports the need for a randomized trial to evaluate the safest and most efficacious reconstruction techniques.
ISSN: 15737217
Appears in Collections:Scopus 2018

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