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Title: Heavy Coffee Consumption and Risk of Pancreatitis: A Systematic Review and Meta-Analysis
Authors: Karn Wijarnpreecha
Panadeekarn Panjawatanan
Omar Y. Mousa
Wisit Cheungpasitporn
Surakit Pungpapong
Patompong Ungprasert
Faculty of Medicine, Siriraj Hospital, Mahidol University
University of Mississippi Medical Center
Mayo Clinic in Jacksonville, Florida
Chiang Mai University
Bassett Medical Center
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Nov-2018
Citation: Digestive Diseases and Sciences. Vol.63, No.11 (2018), 3134-3140
Abstract: © 2018, Springer Science+Business Media, LLC, part of Springer Nature. Background/Objectives: Heavy consumption of coffee may have a protective effect against pancreatitis although results from previous studies were inconsistent. This meta-analysis was conducted with the aim to summarize all available data. Methods: This meta-analysis included observational studies that compared the risk of pancreatitis between heavy coffee-drinkers and individuals who were not heavy coffee-drinkers. Pooled risk ratios (RRs) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. Results: Out of 219 retrieved articles, four studies with 351,137 participants met the eligibility criteria and were included in the analysis. The risk of pancreatitis among heavy coffee-drinkers was significantly lower than individuals who were not heavy coffee-drinkers with the pooled RR of 0.78 (95% CI 0.67–0.91). The statistical heterogeneity between the studies was insignificant (I 2 = 0%). Conclusions: This meta-analysis demonstrated a significantly decreased risk of pancreatitis among heavy coffee-drinkers. However, further investigations are still required to determine causality and potential clinical application.
ISSN: 15732568
Appears in Collections:Scopus 2018

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