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Title: Insight into the influence of cultivar type, cultivation year, and site on the lignans and related phenolic profiles, and the health-promoting antioxidant potential of flax (linum usitatissimum L.) seeds
Authors: Laurine Garros
Samantha Drouet
Cyrielle Corbin
Cédric Decourtil
Thibaud Fidel
Julie Lebas De Lacour
Emilie A. Leclerc
Sullivan Renouard
Duangjai Tungmunnithum
Joël Doussot
Bilal Haider Abassi
Benoit Maunit
Éric Lainé
Ophélie Fliniaux
François Mesnard
Christophe Hano
Quaid-i-Azam University
Universite d'Orleans
Université de Picardie Jules Verne
Conservatoire National des Arts et Metiers
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 14-Oct-2018
Citation: Molecules. Vol.23, No.10 (2018)
Abstract: © 2018 by the Authors. Flaxseeds are a functional food representing, by far, the richest natural grain source of lignans, and accumulate substantial amounts of other health beneficial phenolic compounds (i.e., flavonols, hydroxycinnamic acids). This specific accumulation pattern is related to their numerous beneficial effects on human health. However, to date, little data is available concerning the relative impact of genetic and geographic parameters on the phytochemical yield and composition. Here, the major influence of the cultivar over geographic parameters on the flaxseed phytochemical accumulation yield and composition is evidenced. The importance of genetic parameters on the lignan accumulation was further confirmed by gene expression analysis monitored by RT-qPCR. The corresponding antioxidant activity of these flaxseed extracts was evaluated, both in vitro, using ferric reducing antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC), and iron chelating assays, as well as in vivo, by monitoring the impact of UV-induced oxidative stress on the lipid membrane peroxidation of yeast cells. Our results, both the in vitro and in vivo studies, confirm that flaxseed extracts are an effective protector against oxidative stress. The results point out that secoisolariciresinol diglucoside, caffeic acid glucoside, and p-coumaric acid glucoside are the main contributors to the antioxidant capacity. Considering the health benefits of these compounds, the present study demonstrates that the flaxseed cultivar type could greatly influence
ISSN: 14203049
Appears in Collections:Scopus 2018

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