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dc.contributor.authorLaurine Garrosen_US
dc.contributor.authorSamantha Droueten_US
dc.contributor.authorCyrielle Corbinen_US
dc.contributor.authorCédric Decourtilen_US
dc.contributor.authorThibaud Fidelen_US
dc.contributor.authorJulie Lebas De Lacouren_US
dc.contributor.authorEmilie A. Leclercen_US
dc.contributor.authorSullivan Renouarden_US
dc.contributor.authorDuangjai Tungmunnithumen_US
dc.contributor.authorJoël Doussoten_US
dc.contributor.authorBilal Haider Abassien_US
dc.contributor.authorBenoit Mauniten_US
dc.contributor.authorÉric Lainéen_US
dc.contributor.authorOphélie Fliniauxen_US
dc.contributor.authorFrançois Mesnarden_US
dc.contributor.authorChristophe Hanoen_US
dc.contributor.otherQuaid-i-Azam Universityen_US
dc.contributor.otherUniversite d'Orleansen_US
dc.contributor.otherUniversité de Picardie Jules Verneen_US
dc.contributor.otherConservatoire National des Arts et Metiersen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherCNRS GDR3711en_US
dc.identifier.citationMolecules. Vol.23, No.10 (2018)en_US
dc.description.abstract© 2018 by the Authors. Flaxseeds are a functional food representing, by far, the richest natural grain source of lignans, and accumulate substantial amounts of other health beneficial phenolic compounds (i.e., flavonols, hydroxycinnamic acids). This specific accumulation pattern is related to their numerous beneficial effects on human health. However, to date, little data is available concerning the relative impact of genetic and geographic parameters on the phytochemical yield and composition. Here, the major influence of the cultivar over geographic parameters on the flaxseed phytochemical accumulation yield and composition is evidenced. The importance of genetic parameters on the lignan accumulation was further confirmed by gene expression analysis monitored by RT-qPCR. The corresponding antioxidant activity of these flaxseed extracts was evaluated, both in vitro, using ferric reducing antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC), and iron chelating assays, as well as in vivo, by monitoring the impact of UV-induced oxidative stress on the lipid membrane peroxidation of yeast cells. Our results, both the in vitro and in vivo studies, confirm that flaxseed extracts are an effective protector against oxidative stress. The results point out that secoisolariciresinol diglucoside, caffeic acid glucoside, and p-coumaric acid glucoside are the main contributors to the antioxidant capacity. Considering the health benefits of these compounds, the present study demonstrates that the flaxseed cultivar type could greatly influenceen_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleInsight into the influence of cultivar type, cultivation year, and site on the lignans and related phenolic profiles, and the health-promoting antioxidant potential of flax (linum usitatissimum L.) seedsen_US
Appears in Collections:Scopus 2018

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