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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/45049
Title: Depsides and depsidones from the soil-derived fungus Aspergillus unguis PSU-RSPG204
Authors: Patima Phainuphong
Vatcharin Rukachaisirikul
Souwalak Phongpaichit
Jariya Sakayaroj
Phongthon Kanjanasirirat
Suparerk Borwornpinyo
Nattaphong Akrimajirachoote
Chantapol Yimnual
Chatchai Muanprasat
Walailak University
Mahidol University
Prince of Songkla University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 27-Sep-2018
Citation: Tetrahedron. Vol.74, No.39 (2018), 5691-5699
Abstract: © 2018 Elsevier Ltd Three new depsides, aspergisides A-C, and one new depsidone, aspergisidone, were isolated from the soil-derived fungus Aspergillus unguis PSU-RSPG204 together with one phthalide derivative and 11 depsidones including emeguisin A, aspersidone and folipastatin. The structures were determined by spectroscopic evidence. Aspersidone and emeguisin A showed remarkably antibacterial activity against Staphylococcus aureus and methicillin-resistance S. aureus with equal MIC values of 0.5 μg/mL. Emeguisin A, which displayed the highest activity with 87.06% inhibition of human colon carcinoma (HCT-116) cell viability, decreased numbers of live cells/numbers of dead cells in a dose-dependent manner with the IC50 values of 34.8–84.7 μM in a 3D culture model depending on durations of incubation. In addition, folipastatin dose-dependently inhibited forskolin-stimulated chloride secretion in human intestinal epithelial (T84) cells with an IC50 value of 0.5 μM. These depsidones were considered to be inactive against noncancerous Vero Cells with the IC50 values of >10 μM.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85051529528&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/45049
ISSN: 14645416
00404020
Appears in Collections:Scopus 2018

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