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Title: Insulin does not rescue cortical and trabecular bone loss in type 2 diabetic Goto-Kakizaki rats
Authors: Ratchaneevan Aeimlapa
Narattaphol Charoenphandhu
Panan Suntornsaratoon
Kannikar Wongdee
Wacharaporn Tiyasatkulkovit
Kanchana Kengkoom
Nateetip Krishnamra
Chulalongkorn University
Mahidol University
Burapha University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Sep-2018
Citation: Journal of Physiological Sciences. Vol.68, No.5 (2018), 531-540
Abstract: © 2017, The Physiological Society of Japan and Springer Japan KK. In type 2 diabetes mellitus (T2DM), the decreased bone strength is often associated with hyperglycemia and bone cell insulin resistance. Since T2DM is increasingly reported in young adults, it is not known whether the effect of T2DM on bone would be different in young adolescents and aging adults. Here, we found shorter femoral and tibial lengths in 7-month, but not 13-month, Goto-Kakizaki (GK) T2DM rats as compared to wild-type rats. Bone µCT analysis showed long-lasting impairment of both cortical and trabecular bones in GK rats. Although insulin treatment effectively improved hyperglycemia, it was not able to rescue trabecular BMD and cortical thickness in young adult GK rats. In conclusion, insulin treatment and alleviation of hyperglycemia did not increase BMD of osteopenic GK rats. It is likely that early prevention of insulin resistance should prevail over treatment of full-blown T2DM-related osteopathy.
ISSN: 18806546
Appears in Collections:Scopus 2018

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