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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/45072
Title: Rapid design and fielding of four diagnostic technologies in Sierra Leone, Thailand, Peru, and Australia: Successes and challenges faced introducing these biosensors
Authors: Shawn P. Mulvaney
Lisa A. Fitzgerald
Leila J. Hamdan
Bradley R. Ringeisen
Emily R. Petersen
Jaimee R. Compton
Nina L. McAuliff
Tomasz A. Leski
Chris R. Taitt
David A. Stenger
Christopher A. Myers
Erin Hansen
Michelle Ricketts
Chelsea Hoegberg
Kamonthip Homdayjanakul
Rashid Ansumana
Joseph M. Lamin
Umaru Bangura
Joseph Lahai
Victoria Baio
Direk Limmathurotsakul
Gumphol Wongsuvan
Viriya Hantrakun
Supaporn Wacharapluesadee
Anek Mungaomklang
Opass Putcharoen
Pratoomtong Yatoom
Kriengsak Kruthakool
Robert D. Hontz
Christopher Mores
Crystyan Siles
Amy Morrison
Mark Mayo
Bart J. Currie
Kathryn H. Jacobsen
Kathleen Quinn
Jerold Blutman
Flavia Amariei
John Hannan
Naval Medical Research Unit No. 6
Chulalongkorn University
Naval Research Laboratory
Menzies School of Health Research
George Mason University, Fairfax Campus
HJF
Mahidol University
Nuffield Department of Clinical Medicine
Royal Darwin Hospital
Naval Medical Center San Diego
Nova Research, Inc.
Pak Thong Chai Hospital
Farm Chokchai(®)
Mercy Hospital Research Laboratory
Nakhon Ratchasima College
Defense Threat Reduction Agency
Keywords: Biochemistry, Genetics and Molecular Biology;Computer Science;Engineering;Materials Science
Issue Date: 1-Sep-2018
Citation: Sensing and Bio-Sensing Research. Vol.20, (2018), 22-33
Abstract: © 2018 Febrile illnesses are among the most common reasons for visits to hospitals and clinics worldwide. Since fevers can arise from a wide range of diseases, identifying the causative pathogen is essential not only for effective personal treatment but also for early detection of outbreaks. The Defense Threat Reduction Agency (DTRA) tasked a coalition of commercial, academic, and government researchers with moving diagnostic technology concepts from ideation to field use as rapidly as possible using scientifically sound evaluations. DTRA's 24 Month Challenge program examined >30 technologies before fielding four technologies on four continents. >10,000 in field test results were recorded. Here we discuss our tiered evaluation system to assess candidate technologies developed by commercial partners and the process of field testing those technologies at various front-line clinics in Sierra Leone, Thailand, Peru, and Australia. We discuss successes and challenges for introducing two multiplexed lateral flow immunoassay (LFI) tests that detect malaria, dengue fever, melioidosis, and the plague. Additionally we discuss the use of a LFI reader that assisted the interpretation of the assay, communicated results to a data cloud, and greatly facilitated reach-back support. Lastly, we discuss the concurrent field testing of a multiplexed PCR assay on the FilmArray platform, which had an assay pouch specially designed for the 24 Month Challenge. Either standard-of-care or gold-standard testing were run alongside our fielded technologies to benchmark their performance.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049308452&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/45072
ISSN: 22141804
Appears in Collections:Scopus 2018

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