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Title: Measurement properties of the ASAS Health Index: Results of a global study in patients with axial and peripheral spondyloarthritis
Authors: Uta Kiltz
Désirée Van Der Heijde
Annelies Boonen
Nurullah Akkoc
Wilson Bautista-Molano
Ruben Burgos-Vargas
James Cheng Chung Wei
Praveena Chiowchanwisawakit
Maxime Dougados
M. Tuncay Duruoz
Bassel Kamal Elzorkany
Inna Gaydukova
Lianne S. Gensler
Michele Gilio
Simeon Grazio
Jieruo Gu
Robert D. Inman
Tae Jong Kim
Victoria Navarro-Compan
Helena Marzo-Ortega
Salih Ozgocmen
Fernando Pimentel Dos Santos
Michael Schirmer
Simon Stebbings
Filip E. Van Den Bosch
Astrid Van Tubergen
Juergen Braun
Universidad Militar Nueva Granada
Chung Shan Medical University Hospital
Università degli studi Magna Graecia di Catanzaro
University Hospital of Ghent
Universiteit Gent
Universidad Nacional Autónoma de México
Universidade Nova de Lisboa
Rheumazentrum Ruhrgebiet St. Josefs-Krankenhaus
Hospital Universitario La Paz
Marmara Üniversitesi
Guangzhou University
University of California, San Francisco
Hopital Cochin AP-HP
North-Western State Medical University named after I.I. Mechnikov
University of Toronto
Leiden University Medical Center - LUMC
Mahidol University
University of Leeds
Dunedin School of Medicine
Cairo University
Medizinische Universitat Innsbruck
University Hospital Maastricht
Chonnam National University
University of Zagreb School of Medicine
Medical Park Gaziosmanpaşa Hospital
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 1-Sep-2018
Citation: Annals of the Rheumatic Diseases. Vol.77, No.9 (2018), 1311-1317
Abstract: © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Objectives To evaluate construct validity, interpretability, reliability and responsiveness as well as determination of cut-off points for good and poor health within the original English version and the 18 translations of the disease-specific Assessment of Spondyloarthritis international Society Health Index (ASAS HI) in 23 countries worldwide in patients with spondyloarthritis (SpA). Methods A representative sample of patients with SpA fulfilling the ASAS classification criteria for axial (axSpA) or peripheral SpA was used. The construct validity of the ASAS HI was tested using Spearman correlation with several standard health outcomes for axSpA. Test-retest reliability was assessed by intraclass correlation coefficients (ICCs) in patients with stable disease (interval 4-7 days). In patients who required an escalation of therapy because of high disease activity, responsiveness was tested after 2-24weeks using standardised response mean (SRM). Results Among the 1548 patients, 64.9% were men, with a mean (SD) age 42.0 (13.4) years. Construct validity ranged from low (age: 0.10) to high (Bath AnkylosingSpondylitisFunctioning Index: 0.71). Internal consistency was high (Cronbach's α of 0.93). The reliability among 578 patients was good (ICC=0.87 (95% CI 0.84 to 0.89)). Responsiveness among 246 patients was moderate-large (SRM=-0.44 for non-steroidal anti-inflammatory drugs, -0.69 for conventional synthetic disease-modifying antirheumatic drug and -0.85 for tumour necrosis factor inhibitor). The smallest detectable change was 3.0. Values ≤5.0 have balanced specificity to distinguish good health as opposed to moderate health, and values ≥12.0 are specific to represent poor health as opposed to moderate health. Conclusions The ASAS HI proved to be valid, reliable and responsive. It can be used to evaluate the impact of SpA and its treatment on functioning and health. Furthermore, comparison of disease impact between populations is possible.
ISSN: 14682060
Appears in Collections:Scopus 2018

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