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dc.contributor.authorChonlaphat Sukasemen_US
dc.contributor.authorTheodora Katsilaen_US
dc.contributor.authorTherdpong Temparken_US
dc.contributor.authorGeorge P. Patrinosen_US
dc.contributor.authorWasun Chantratitaen_US
dc.contributor.otherCollege of Medicine and Health Sciences United Arab Emirates Universityen_US
dc.contributor.otherPanepistimion Patronen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
dc.identifier.citationAnnual Review of Genomics and Human Genetics. Vol.19, (2018), 329-353en_US
dc.description.abstractCopyright © 2018 by Annual Reviews. All rights reserved. The Global Genomic Medicine Collaborative, a multinational coalition of genomic and policy experts working to implement genomics in clinical care, considers pharmacogenomics to be among the first areas in genomic medicine that can provide guidance in routine clinical practice, by linking genetic variation and drug response. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe life-threatening reactions to medications with a high incidence worldwide. Genomic screening prior to drug administration is a key opportunity and potential paradigm for using genomic medicine to reduce morbidity and mortality and ultimately eliminate one of the most devastating adverse drug reactions. This review focuses on the current understanding of the surveillance, pathogenesis, and treatment of SJS/TEN, including the role of genomics and pharmacogenomics in the etiology, treatment, and eradication of preventable causes of drug-induced SJS/TEN. Gaps, unmet needs, and priorities for future research have been identified for the optimal management of drug-induced SJS/TEN in various ethnic populations. Pharmacogenomics holds great promise for optimal patient stratification and theranostics, yet its clinical implementation needs to be cost-effective and sustainable.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleDrug-induced stevens-johnson syndrome and toxic epidermal necrolysis call for optimum patient stratification and theranostics via pharmacogenomicsen_US
Appears in Collections:Scopus 2018

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