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Title: Inhaled nebulized sodium nitrite decreases pulmonary artery pressure in β-thalassemia patients with pulmonary hypertension
Authors: Teerapat Yingchoncharoen
Teewin Rakyhao
Suporn Chuncharunee
Piyamitr Sritara
Pavit Pienvichit
Kittiphong Paiboonsukwong
Piyadon Sathavorasmith
Kanjana Sirirat
Thanaporn Sriwantana
Sirada Srihirun
Nathawut Sibmooh
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jun-2018
Citation: Nitric Oxide - Biology and Chemistry. Vol.76, (2018), 174-178
Abstract: © 2017 Elsevier Inc. Pulmonary hypertension is a life-threatening complication in β-thalassemia. Inhaled sodium nitrite has vasodilatory effect on pulmonary vasculature. However, its effect on pulmonary artery pressure (PAP) in β-thalassemia subjects with pulmonary hypertension has never been reported. In this study, we investigated the change in PAP during inhalation of sodium nitrite in 5 β-thalassemia patients. We demonstrated that sodium nitrite administered by nebulization rapidly decreased PAP as measured by echocardiography and right heart catheterization. The effect of nitrite was short as PAP returned to baseline at end of inhalation. Our findings support acute pulmonary vasodilation effect of nitrite in β-thalassemia with pulmonary hypertension.
ISSN: 10898611
Appears in Collections:Scopus 2018

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