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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/45157
Title: Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys
Authors: Peter Abbink
Rafael A. Larocca
Wanwisa Dejnirattisai
Rebecca Peterson
Joseph P. Nkolola
Erica N. Borducchi
Piyada Supasa
Juthathip Mongkolsapaya
Gavin R. Screaton
Dan H. Barouch
University of Oxford
Massachusetts Institute of Technology
Imperial College London
Faculty of Medicine, Siriraj Hospital, Mahidol University
Harvard Medical School
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jun-2018
Citation: Nature Medicine. Vol.24, No.6 (2018), 721-723
Abstract: © 2018 The Author(s). Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potently cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048016859&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/45157
ISSN: 1546170X
10788956
Appears in Collections:Scopus 2018

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