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Title: Anti-HLA alloantibodies of the IgA isotype in re-transplant candidates part II: Correlation with graft survival
Authors: M. L. Arnold
C. Bach
F. M. Heinemann
P. A. Horn
M. Ziemann
N. Lachmann
A. Mühlbacher
A. Dick
A. Ender
D. Thammanichanond
S. Schaub
G. Hönger
G. F. Fischer
J. Mytilineos
M. Hallensleben
W. E. Hitzler
C. Seidl
B. M. Spriewald
Klinikum Stuttgart Katharinenhospital
University of Basel, Institute for Medical Microbiology
Universitätsklinik Erlangen und Medizinische Fakultät
Charité – Universitätsmedizin Berlin
Medizinische Hochschule Hannover (MHH)
Klinikum der Johannes-Gutenberg-Universität und Fachbereich Medizin
University Hospital Innsbruck
Mahidol University
Medizinische Universitat Wien
Universitätsklinikum Ulm
Universitäts Klinikum Essen und Medizinische Fakultät
Universitätskliniken Schleswig-Holstein
Klinikum der Universität München
Institute for Transfusion Medicine and Immunohaematology
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 1-Jun-2018
Citation: International Journal of Immunogenetics. Vol.45, No.3 (2018), 95-101
Abstract: © 2018 The Authors. International Journal of Immunogenetics Published by John Wiley & Sons Ltd. We reported previously on the widespread occurrence of anti-HLA alloantibodies of the IgA isotype (anti-HLA IgA) in the sera of solid-organ re-transplantation (re-tx) candidates (Arnold et al.,). Specifically focussing on kidney re-tx patients, we now extended our earlier findings by examining the impact of the presence and donor specificity of anti-HLA IgA on graft survival. We observed frequent concurrence of anti-HLA IgA and anti-HLA IgG in 27% of our multicenter collective of 694 kidney re-tx patients. This subgroup displayed significantly reduced graft survival as evidenced by the median time to first dialysis after transplantation (TTD 77 months) compared to patients carrying either anti-HLA IgG or IgA (TTD 102 and 94 months, respectively). In addition, donor specificity of anti-HLA IgA had a significant negative impact on graft survival (TTD 74 months) in our study. Taken together, our data strongly indicate that presence of anti-HLA IgA, in particular in conjunction with anti-HLA-IgG, in sera of kidney re-tx patients is associated with negative transplantation outcome.
ISSN: 1744313X
Appears in Collections:Scopus 2018

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