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dc.contributor.authorM. L. Arnolden_US
dc.contributor.authorC. Bachen_US
dc.contributor.authorF. M. Heinemannen_US
dc.contributor.authorP. A. Hornen_US
dc.contributor.authorM. Ziemannen_US
dc.contributor.authorN. Lachmannen_US
dc.contributor.authorA. Mühlbacheren_US
dc.contributor.authorA. Dicken_US
dc.contributor.authorA. Enderen_US
dc.contributor.authorD. Thammanichanonden_US
dc.contributor.authorS. Schauben_US
dc.contributor.authorG. Höngeren_US
dc.contributor.authorG. F. Fischeren_US
dc.contributor.authorJ. Mytilineosen_US
dc.contributor.authorM. Hallenslebenen_US
dc.contributor.authorW. E. Hitzleren_US
dc.contributor.authorC. Seidlen_US
dc.contributor.authorB. M. Spriewalden_US
dc.contributor.otherKlinikum Stuttgart Katharinenhospitalen_US
dc.contributor.otherUniversity of Basel, Institute for Medical Microbiologyen_US
dc.contributor.otherUniversitätsklinik Erlangen und Medizinische Fakultäten_US
dc.contributor.otherCharité – Universitätsmedizin Berlinen_US
dc.contributor.otherMedizinische Hochschule Hannover (MHH)en_US
dc.contributor.otherKlinikum der Johannes-Gutenberg-Universität und Fachbereich Medizinen_US
dc.contributor.otherUniversity Hospital Innsbrucken_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherMedizinische Universitat Wienen_US
dc.contributor.otherUniversitätsklinikum Ulmen_US
dc.contributor.otherUniversitäts Klinikum Essen und Medizinische Fakultäten_US
dc.contributor.otherUniversitätskliniken Schleswig-Holsteinen_US
dc.contributor.otherKlinikum der Universität Münchenen_US
dc.contributor.otherInstitute for Transfusion Medicine and Immunohaematologyen_US
dc.date.accessioned2019-08-23T10:33:14Z-
dc.date.available2019-08-23T10:33:14Z-
dc.date.issued2018-06-01en_US
dc.identifier.citationInternational Journal of Immunogenetics. Vol.45, No.3 (2018), 95-101en_US
dc.identifier.issn1744313Xen_US
dc.identifier.issn17443121en_US
dc.identifier.other2-s2.0-85044380417en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044380417&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/45159-
dc.description.abstract© 2018 The Authors. International Journal of Immunogenetics Published by John Wiley & Sons Ltd. We reported previously on the widespread occurrence of anti-HLA alloantibodies of the IgA isotype (anti-HLA IgA) in the sera of solid-organ re-transplantation (re-tx) candidates (Arnold et al.,). Specifically focussing on kidney re-tx patients, we now extended our earlier findings by examining the impact of the presence and donor specificity of anti-HLA IgA on graft survival. We observed frequent concurrence of anti-HLA IgA and anti-HLA IgG in 27% of our multicenter collective of 694 kidney re-tx patients. This subgroup displayed significantly reduced graft survival as evidenced by the median time to first dialysis after transplantation (TTD 77 months) compared to patients carrying either anti-HLA IgG or IgA (TTD 102 and 94 months, respectively). In addition, donor specificity of anti-HLA IgA had a significant negative impact on graft survival (TTD 74 months) in our study. Taken together, our data strongly indicate that presence of anti-HLA IgA, in particular in conjunction with anti-HLA-IgG, in sera of kidney re-tx patients is associated with negative transplantation outcome.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044380417&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleAnti-HLA alloantibodies of the IgA isotype in re-transplant candidates part II: Correlation with graft survivalen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1111/iji.12363en_US
Appears in Collections:Scopus 2018

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