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Title: Application of a novel anti-adhesive membrane, E8002, in a rat laminectomy model
Authors: Kiyoshi Kikuchi
Kentaro Setoyama
Takuto Terashi
Megumi Sumizono
Salunya Tancharoen
Shotaro Otsuka
Seiya Takada
Kazuki Nakanishi
Koki Ueda
Harutoshi Sakakima
Ko Ichi Kawahara
Ikuro Maruyama
Gohsuke Hattori
Motohiro Morioka
Eiichiro Tanaka
Hisaaki Uchikado
Osaka Institute of Technology
Kagoshima University
Mahidol University
Kurume University School of Medicine
Uchikado Neuro-Spine Clinic
Keywords: Biochemistry, Genetics and Molecular Biology;Chemical Engineering;Chemistry;Computer Science
Issue Date: 18-May-2018
Citation: International Journal of Molecular Sciences. Vol.19, No.5 (2018)
Abstract: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Neuropathic pain after spinal surgery, so-called failed back surgery syndrome, is a frequently observed common complication. One cause of the pain is scar tissue formation, observed as post-surgical epidural adhesions. These adhesions may compress surrounding spinal nerves, resulting in pain, even after successful spinal surgery. E8002 is an anti-adhesive membrane. In Japan, a clinical trial of E8002 is currently ongoing in patients undergoing abdominal surgery. However, animal experiments have not been performed for E8002 in spinal surgery. We assessed the anti-adhesive effect of E8002 in a rat laminectomy model. The dura matter was covered with an E8002 membrane or left uncovered as a control. Neurological evaluations and histopathological findings were compared at six weeks postoperatively. Histopathological analyses were performed by hematoxylin–eosin and aldehyde fuchsin-Masson Goldner staining. Three assessment areas were selected at the middle and margins of the laminectomy sites, and the numbers of fibroblasts and inflammatory cells were counted. Blinded histopathological evaluation revealed that adhesions and scar formation were reduced in the E8002 group compared with the control group. The E8002 group had significantly lower numbers of fibroblasts and inflammatory cells than the control group. The present results indicate that E8002 can prevent epidural scar adhesions after laminectomy.
ISSN: 14220067
Appears in Collections:Scopus 2018

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