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|Title:||Synthetic analogues of durantoside I from Citharexylum spinosum L. and their cytotoxic activity|
Rambhai Barni Rajabhat University
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Bioorganic and Medicinal Chemistry Letters. Vol.28, No.9 (2018), 1558-1561|
|Abstract:||© 2018 Elsevier Ltd New iridoid glycoside derivatives from durantoside I, the latter from the dried flowers and leaves of Citharexylum spinosum, were synthesized by variously modifying a sugar moiety by silylation or acetylation and/or removal of cinnamate group at C-7 position and subsequent screening for comparative cytotoxicity against several cancer cell lines. Addition of alkylsilane to durantoside I and removal of cinnamate group were most effective in improving cytotoxicity.|
|Appears in Collections:||Scopus 2018|
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