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Title: Synthetic analogues of durantoside I from Citharexylum spinosum L. and their cytotoxic activity
Authors: Jutamas Apisornopas
Patamawadee Silalai
Teerapich Kasemsuk
Anan Athipornchai
Uthaiwan Sirion
Kanoknetr Suksen
Pawinee Piyachaturawat
Apichart Suksamrarn
Rungnapha Saeeng
Rambhai Barni Rajabhat University
Ramkhamhaeng University
Mahidol University
Burapha University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 15-May-2018
Citation: Bioorganic and Medicinal Chemistry Letters. Vol.28, No.9 (2018), 1558-1561
Abstract: © 2018 Elsevier Ltd New iridoid glycoside derivatives from durantoside I, the latter from the dried flowers and leaves of Citharexylum spinosum, were synthesized by variously modifying a sugar moiety by silylation or acetylation and/or removal of cinnamate group at C-7 position and subsequent screening for comparative cytotoxicity against several cancer cell lines. Addition of alkylsilane to durantoside I and removal of cinnamate group were most effective in improving cytotoxicity.
ISSN: 14643405
Appears in Collections:Scopus 2018

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