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Title: Cervical Cancer Markers: Epigenetics and microRNAs
Authors: Vishuda Laengsri
Usanee Kerdpin
Chotiros Plabplueng
Lertyot Treeratanapiboon
Pornlada Nuchnoi
Naresuan University
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 21-Mar-2018
Citation: Lab Medicine. Vol.49, No.2 (2018), 97-111
Abstract: © American Society for Clinical Pathology 2018. All rights reserved. Gynecologic malignant neoplasms are a severe health problem among female patients, of which cervical cancer (CC), in particular, is a common disease leading to high mortality rates. Despite extensive attempts by researchers to solve the molecular mystery of CC, the mechanisms of its pathogenesis remain unclear. Tumor markers used in the clinical laboratory, such as squamous cell carcinoma (SCC), cancer antigen (CA)-125, and CA19-9, provide some help in diagnosing patients with CC. However, finding new molecular markers with high sensitivity and specificity is necessary. This review focuses on the role of epigenetic changes, particularly microRNAs (miRNAs), to CC. Several miRNAs that associated with CC potentially have the advantage of being early biomarkers. Moreover, altered serum miRNAs or single nucleotide polymorphisms in miRNA patterns may predict disease progression.
ISSN: 19437730
Appears in Collections:Scopus 2018

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