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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/45264
Title: Ophiobolins from the Mangrove Fungus Aspergillus ustus
Authors: Tonghan Zhu
Zhenyu Lu
Jie Fan
Liping Wang
Guoliang Zhu
Yi Wang
Xia Li
Kui Hong
Pawinee Piyachaturawat
Arthit Chairoungdua
Weiming Zhu
Shandong University, Weihai
Wuhan University
Ocean University of China
Chinese Academy of Sciences
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 26-Jan-2018
Citation: Journal of Natural Products. Vol.81, No.1 (2018), 2-9
Abstract: © 2017 The American Chemical Society and American Society of Pharmacognosy. Seven new ophiobolins (1-5, 12, and 14) along with the 11 known analogues (6-11, 13, 15-18) were isolated from the ethyl acetate extracts of the liquid and solid cultures of the mangrove fungus Aspergillus ustus 094102. The structures including the absolute configurations of the seven new compounds were elucidated by spectroscopic analysis, chemical methods, and quantum ECD calculations. Compounds 4-8 and 11-15 showed cytotoxicities against the G3K, MCF-7, MD-MBA-231, MCF/Adr, A549, and HL-60 human cancer cell lines with the IC 50 values ranging from 0.6 to 9.5 μM.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85041213491&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/45264
ISSN: 15206025
01633864
Appears in Collections:Scopus 2018

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