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dc.contributor.authorThanaporn Sriwantanaen_US
dc.contributor.authorPornpun Vivithanapornen_US
dc.contributor.authorKittiphong Paiboonsukwongen_US
dc.contributor.authorKrit Rattanawonsakulen_US
dc.contributor.authorSirada Srihirunen_US
dc.contributor.authorNathawut Sibmoohen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationCanadian Journal of Physiology and Pharmacology. Vol.96, No.9 (2018), 879-885en_US
dc.description.abstract© 2018, Canadian Science Publishing. All rights reserved. Iron chelation can improve endothelial function. However, effect on endothelial function of deferiprone has not been reported. We hypothesized deferiprone could promote nitric oxide (NO) production in endothelial cells. We studied effects of deferiprone on blood nitrite and blood pressure after single oral dose (25 mg/kg) in healthy subjects and hemoglobin E/β-thalassemia patients. Further, effects of deferiprone on NO production and endothelial NO synthase (eNOS) phosphorylation in primary human pulmonary artery endothelial cells (HPAEC) were investigated in vitro. Blood nitrite levels were higher in patients with deferiprone therapy than those without deferiprone (P = 0.023, n = 16 each). Deferiprone increased nitrite in plasma and whole blood of healthy subjects (P = 0.002 and 0.044) and thalassemia patients (P = 0.003 and 0.046) at time 180 min (n = 20 each). Asymptomatic reduction in diastolic blood pressure (P = 0.005) and increase in heart rate (P = 0.009) were observed in healthy subjects, but not in thalassemia patients. In HPAEC, deferiprone increased cellular nitrite and phospho-eNOS (Ser1177) (P = 0.012 and 0.035, n = 6) without alteration in total eNOS protein and mRNA. We conclude that deferiprone can induce NO production by enhancing eNOS phosphorylation in endothelial cells.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleDeferiprone increases endothelial nitric oxide synthase phosphorylation and nitric oxide productionen_US
Appears in Collections:Scopus 2018

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