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dc.contributor.authorThitinee Vanichapolen_US
dc.contributor.authorSomchai Chutipongtanateen_US
dc.contributor.authorUsanarat Anurathapanen_US
dc.contributor.authorSuradej Hongengen_US
dc.contributor.otherUniversity of Cincinnati College of Medicineen_US
dc.contributor.otherFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
dc.date.accessioned2019-08-23T10:40:00Z-
dc.date.available2019-08-23T10:40:00Z-
dc.date.issued2018-01-01en_US
dc.identifier.citationBioMed Research International. Vol.2018, (2018)en_US
dc.identifier.issn23146141en_US
dc.identifier.issn23146133en_US
dc.identifier.other2-s2.0-85044034915en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044034915&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/45305-
dc.description.abstract© 2018 Thitinee Vanichapol et al. Neuroblastoma (NB) is the most common extracranial solid tumor in childhood with 5-year survival rate of 40% in high-risk patients despite intensive therapies. Recently, adoptive cell therapy, particularly chimeric antigen receptor (CAR) T cell therapy, represents a revolutionary treatment for hematological malignancies. However, there are challenges for this therapeutic strategy with solid tumors, as a result of the immunosuppressive nature of the tumor microenvironment (TME). Cancer cells have evolved multiple mechanisms to escape immune recognition or to modulate immune cell function. Several subtypes of immune cells that infiltrate tumors can foster tumor development, harbor immunosuppressive activity, and decrease an efficacy of adoptive cell therapies. Therefore, an understanding of the dual role of the immune system under the influences of the TME has been crucial for the development of effective therapeutic strategies against solid cancers. This review aims to depict key immune players and cellular pathways involved in the dynamic interplay between the TME and the immune system and also to address challenges and prospective development of adoptive T cell transfer for neuroblastoma.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044034915&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleImmune Escape Mechanisms and Future Prospects for Immunotherapy in Neuroblastomaen_US
dc.typeReviewen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1155/2018/1812535en_US
Appears in Collections:Scopus 2018

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