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Title: CYP2D6 genotype analysis of a Thai population: Platform comparison
Authors: Monpat Chamnanphon
Andrea Gaedigk
Natchaya Vanwong
Nopphadol Nuntamool
Yaowaluck Hongkaew
Apichaya Puangpetch
Chonlaphat Sukasem
Chulalongkorn University
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
University of Missouri-Kansas City
Payap University
Keywords: Biochemistry, Genetics and Molecular Biology;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2018
Citation: Pharmacogenomics. Vol.19, No.12 (2018), 947-960
Abstract: © 2018 Future Medicine Ltd. The highly polymorphic CYP2D6 gene locus leads to a wide range of enzyme activity. Since there are limited data for Thai, the major aim was to investigate CYP2D6 genetic variation in a large Thai population (n = 920). CYP2D6 genotyping was performed using four different platforms. Genotype call rates of the Luminex xTAG® and AmpliChip CYP450 test were 96.5% and 87.4%, respectively. Based on Luminex xTAG® data, the most common alleles and genotypes were ∗1 0 (49.6%), ∗1 (24.6%), ∗2 (10.8%), ∗5 (6.7%), ∗41 (6.5%) and ∗1/∗10 (23.9%), ∗10/∗10 (21.5%), ∗2/∗10 (9.4%), ∗5/∗10 (6.9%), ∗10/∗41 (5.7%), respectively. Challenges and limitations of the platforms evaluated are discussed. These data add to our knowledge regarding interethnic variability in CYP2D6 activity and contribute to improving drug therapy in the Thai.
ISSN: 17448042
Appears in Collections:Scopus 2018

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