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dc.contributor.authorMonpat Chamnanphonen_US
dc.contributor.authorAndrea Gaedigken_US
dc.contributor.authorNatchaya Vanwongen_US
dc.contributor.authorNopphadol Nuntamoolen_US
dc.contributor.authorYaowaluck Hongkaewen_US
dc.contributor.authorApichaya Puangpetchen_US
dc.contributor.authorChonlaphat Sukasemen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
dc.contributor.otherUniversity of Missouri-Kansas Cityen_US
dc.contributor.otherPayap Universityen_US
dc.identifier.citationPharmacogenomics. Vol.19, No.12 (2018), 947-960en_US
dc.description.abstract© 2018 Future Medicine Ltd. The highly polymorphic CYP2D6 gene locus leads to a wide range of enzyme activity. Since there are limited data for Thai, the major aim was to investigate CYP2D6 genetic variation in a large Thai population (n = 920). CYP2D6 genotyping was performed using four different platforms. Genotype call rates of the Luminex xTAG® and AmpliChip CYP450 test were 96.5% and 87.4%, respectively. Based on Luminex xTAG® data, the most common alleles and genotypes were ∗1 0 (49.6%), ∗1 (24.6%), ∗2 (10.8%), ∗5 (6.7%), ∗41 (6.5%) and ∗1/∗10 (23.9%), ∗10/∗10 (21.5%), ∗2/∗10 (9.4%), ∗5/∗10 (6.9%), ∗10/∗41 (5.7%), respectively. Challenges and limitations of the platforms evaluated are discussed. These data add to our knowledge regarding interethnic variability in CYP2D6 activity and contribute to improving drug therapy in the Thai.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleCYP2D6 genotype analysis of a Thai population: Platform comparisonen_US
Appears in Collections:Scopus 2018

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