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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/45336
Title: Peptidoglycan in obligate intracellular bacteria
Authors: Christian Otten
Matteo Brilli
Waldemar Vollmer
Patrick H. Viollier
Jeanne Salje
Università degli Studi di Milano
Mahidol University
Nuffield Department of Clinical Medicine
Newcastle University, United Kingdom
Université de Genève
Università degli Studi di Padova
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 1-Jan-2018
Citation: Molecular Microbiology. Vol.107, No.2 (2018), 142-163
Abstract: © 2017 The Authors. Molecular Microbiology Published by John Wiley & Sons Ltd. Peptidoglycan is the predominant stress-bearing structure in the cell envelope of most bacteria, and also a potent stimulator of the eukaryotic immune system. Obligate intracellular bacteria replicate exclusively within the interior of living cells, an osmotically protected niche. Under these conditions peptidoglycan is not necessarily needed to maintain the integrity of the bacterial cell. Moreover, the presence of peptidoglycan puts bacteria at risk of detection and destruction by host peptidoglycan recognition factors and downstream effectors. This has resulted in a selective pressure and opportunity to reduce the levels of peptidoglycan. In this review we have analysed the occurrence of genes involved in peptidoglycan metabolism across the major obligate intracellular bacterial species. From this comparative analysis, we have identified a group of predicted ‘peptidoglycan-intermediate’ organisms that includes the Chlamydiae, Orientia tsutsugamushi, Wolbachia and Anaplasma marginale. This grouping is likely to reflect biological differences in their infection cycle compared with peptidoglycan-negative obligate intracellular bacteria such as Ehrlichia and Anaplasma phagocytophilum, as well as obligate intracellular bacteria with classical peptidoglycan such as Coxiella, Buchnera and members of the Rickettsia genus. The signature gene set of the peptidoglycan-intermediate group reveals insights into minimal enzymatic requirements for building a peptidoglycan-like sacculus and/or division septum.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85040170589&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/45336
ISSN: 13652958
0950382X
Appears in Collections:Scopus 2018

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