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Title: Glycaemic responses in Asian and non-Asian people with type 2 diabetes initiating insulin glargine 100 units/mL: A patient-level pooled analysis of 16 randomised controlled trials
Authors: Juliana C.N. Chan
Pongamorn Bunnag
Siew P. Chan
Iris T.I. Tan
Shih Tzer Tsai
Ling Gao
Wolfgang Landgraf
Cheng Hsin General Hospital
University of the Philippines Manila
Prince of Wales Hospital Hong Kong
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
University of Malaya Medical Centre
Analysta Inc.
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-2018
Citation: Diabetes Research and Clinical Practice. Vol.135, (2018), 199-205
Abstract: © 2017 Aims To compare outcomes between Asian and non-Asian patients with type 2 diabetes (T2D) inadequately controlled on oral antidiabetic drugs (OADs) initiating insulin glargine 100 units (U)/mL (Gla-100) in randomised controlled clinical trials. Methods Post hoc analysis of patient-level data (Asian n = 235; non-Asian n = 3351) from 16 trials. Results At baseline, Asian patients were younger with lower body mass index (BMI), fasting C-peptide, and fasting plasma glucose (FPG) than non-Asian patients (all P <.001). Asian patients had a higher mean glycosylated haemoglobin (HbA1c) at Week 24 and less reduction in HbA1c from baseline (7.4% vs. 7.2%; −1.3% vs. −1.6%, respectively; P =.0001), and were less likely to achieve HbA1c <7.0% (40% vs. 47%; P =.002) than non-Asian patients. Reductions in FPG and rates of hypoglycaemia were similar between Asian and non-Asian patients. Asian patients had less weight gain than non-Asian patients (+1.3 vs. +1.9 kg, respectively, P =.013). Conclusions In our post hoc meta-analysis, Gla-100 effectively lowers HbA1c and FPG in Asian patients with T2D uncontrolled on OADs with similar incidence of hypoglycaemia and less absolute weight gain compared with non-Asian patients. At a similar FPG reduction, fewer Asian patients achieved HbA1c target <7.0%, suggesting that prandial glucose needs to be addressed.
ISSN: 18728227
Appears in Collections:Scopus 2018

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