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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/45453
Title: New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of: Ziziphus cambodiana
Authors: Natthakaln Lomchoey
Panomwan Panseeta
Pornthip Boonsri
Nuttapon Apiratikul
Samran Prabpai
Palangpon Kongsaeree
Sunit Suksamrarn
Mahidol University
Chulachomklao Royal Military Academy
Srinakharinwirot University
Keywords: Chemical Engineering;Chemistry
Issue Date: 1-Jan-2018
Citation: RSC Advances. Vol.8, No.33 (2018), 18204-18215
Abstract: © The Royal Society of Chemistry 2018. Six new 14-membered ring cyclopeptide alkaloids, cambodines A-F (1-6), and two known compounds, frangufoline (7) and lotusanine B (8), were isolated from the root bark extract of Ziziphus cambodiana Pierre. Their structures and configurations were established based on 1D and 2D NMR, HRMS, ECD, and X-ray crystallographic data. Compounds 1 and 3 are rare 5(14)-type cyclopeptide alkaloids that possess an imidazolidin-4-one ring in the terminal unit. The cyclopeptides were tested for their in vitro antiplasmodial, antitubercular, and cytotoxic effects against three cancer cell lines. Compound 3 showed significant antiplasmodial activity against the malarial parasite Plasmodium falciparum, with an IC50 value of 6.09 μM.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047479838&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/45453
ISSN: 20462069
Appears in Collections:Scopus 2018

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