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|Title:||New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of: Ziziphus cambodiana|
Chulachomklao Royal Military Academy
|Citation:||RSC Advances. Vol.8, No.33 (2018), 18204-18215|
|Abstract:||© The Royal Society of Chemistry 2018. Six new 14-membered ring cyclopeptide alkaloids, cambodines A-F (1-6), and two known compounds, frangufoline (7) and lotusanine B (8), were isolated from the root bark extract of Ziziphus cambodiana Pierre. Their structures and configurations were established based on 1D and 2D NMR, HRMS, ECD, and X-ray crystallographic data. Compounds 1 and 3 are rare 5(14)-type cyclopeptide alkaloids that possess an imidazolidin-4-one ring in the terminal unit. The cyclopeptides were tested for their in vitro antiplasmodial, antitubercular, and cytotoxic effects against three cancer cell lines. Compound 3 showed significant antiplasmodial activity against the malarial parasite Plasmodium falciparum, with an IC50 value of 6.09 μM.|
|Appears in Collections:||Scopus 2018|
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