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Title: Polyketides from the endophytic fungus Cladosporium sp. isolated from the mangrove plant excoecaria agallocha
Authors: Liping Wang
Xiuli Han
Guoliang Zhu
Yi Wang
Arthit Chairoungdua
Pawinee Piyachaturawat
Weiming Zhu
Shandong University of Technology
Ocean University of China
Mahidol University
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology
Guizhou Medical University
Keywords: Chemistry
Issue Date: 1-Aug-2018
Citation: Frontiers in Chemistry. Vol.6, No.AUG (2018)
Abstract: © 2018 Wang, Han, Zhu, Wang, Chairoungdua, Piyachaturawat and Zhu. Five new polyketides (2-6) and ten known compounds (1 and 7-15) were obtained from the fermentation products of the endophytic fungus Cladosporium sp. OUCMDZ-302 with the mangrove plant, Excoecaria agallocha (Euphorbiaceae). The new structures of 2-6 were established on the basis of ECD, specific rotation and spectroscopic data as well as the chemical calculation. Compound 7 showed cytotoxicity against H1975 cell line with an IC50 value of 10.0 μM. Compounds 4 and 8-10 showed radical scavenging activity against DPPH with the IC50 values of 2.65, 0.24, 5.66, and 6.67 μM, respectively. In addition, the absolute configuration of compound 1 was solidly determined by X-ray and sugar analysis of the acidic hydrolysates for the first time as well as those of compounds 8-10 in this paper.
ISSN: 22962646
Appears in Collections:Scopus 2018

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