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|Title:||Aptamer-functionalized DNA nanosphere as a stimuli-responsive nanocarrier|
Faculty of Medicine, Siriraj Hospital, Mahidol University
|Keywords:||Engineering;Materials Science;Physics and Astronomy|
|Citation:||Materials Letters. Vol.214, (2018), 72-75|
|Abstract:||© 2017 Elsevier B.V. Smart nanocarriers that can respond to specific signals have recently gained attention in clinical research. Through the scaffolded DNA origami technique, we developed an aptamer-functionalized DNA nanosphere that could change its conformation upon binding to cancer-specific Mucin 1 protein (MUC1). A MUC1 aptamer was added into the lock-and-key system of the DNA nanosphere, and specific binding of the aptamer and MUC1 triggered the opening of the structure. A decrease in FRET signals demonstrated that the DNA nanosphere underwent structural change to the open conformation in response to the MUC1-containing cell lysate. Gold nanoparticles were also successfully encapsulated inside the cavity, implicating its loading ability. Our data confirmed that the aptamer-modified DNA nanosphere has proved to be a responsive nanocarrier and may serve as a promising candidate for cancer theranostic purposes.|
|Appears in Collections:||Scopus 2018|
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