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Title: Intrinsic toxicity of stable nanosized titanium dioxide using polyacrylate in human keratinocytes
Authors: Preeyaporn Koedrith
Yeo Jin Kim
Younghun Kim
Joo Hyon Kang
Young Rok Seo
Faculty of Environment and Resource Studies, Mahidol University
Kwangwoon University
Dongguk University, Seoul
Institute of Environmental Medicine for Green Chemistry
Keywords: Environmental Science;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jul-2018
Citation: Molecular and Cellular Toxicology. Vol.14, No.3 (2018), 273-282
Abstract: © 2018, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V. Backgrounds: Trends in the use of an anticoagulant as a dispersing stabilizer are addressed. An effective approach to preparing stable nanosized titanium dioxide (nTiO 2 ) for accurate and systematic assessment of nano- toxicity has not been established. Methods: Among the dispersants tested here, it was found that sodium polyacrylate (PAA) was the most effective dispersant for nTiO 2 in culture media. Our study was the first to demonstrate that a stable PAA-dispersed nTiO 2 (nTiO 2 /PAA) suspension showed more toxic than nTiO 2 without PAA in human HaCaT keratinocytes. Results: Initially, MTT results showed that the stable nTiO 2 /PAA dispersion exhibited significantly greater cytotoxicity than nTiO 2 without PAA. In addition, the stable nTiO 2 /PAA dispersion induced markedly more oxidative stress than nTiO 2 without PAA. Importantly, the stable nTiO 2 /PAA dispersion caused DNA breakage to a greater extent than nTiO 2 without PAA. Conclusion: Our findings indicated that the anti-coagulant PAA is suitable for preparing homologous dispersed nTiO 2 under realistic physiological culture test conditions.
ISSN: 20928467
Appears in Collections:Scopus 2018

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