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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/45933
Title: Sensitivity and specificity of a lateral flow immunoassay (LFI) in serum samples for diagnosis of melioidosis
Authors: Gumphol Wongsuvan
Viriya Hantrakun
Prapit Teparrukkul
Mallika Imwong
T. Eoin West
Vanaporn Wuthiekanun
Nicholas P.J. Day
David Aucoin
Direk Limmathurotsakul
University of Oxford
University of Washington, Seattle
Mahidol University
University of Nevada School of Medicine
Sunpasitthiprasong Hospital
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Dec-2018
Citation: Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.112, No.12 (2018), 568-570
Abstract: © 2018 The Author(s). Background Culture is the gold standard for the diagnosis of melioidosis, an infection caused by Burkholderia pseudomallei. Here we evaluate a lateral flow immunoassay (LFI) to detect B. pseudomallei capsular polysaccharide (CPS) in serum samples. Methods Patients with culture from any clinical specimen positive for B. pseudomallei were selected as cases. Patients who were blood culture positive for Staphylococcus aureus, Escherichia coli or Klebsiella pneumoniae as well as those who were malaria or dengue polymerase chain reaction assay positive were selected as controls. Results The sensitivity of the LFI was 31.3% (60/192 case patients [95% confidence interval {CI} 24.8 to 38.3]) and the specificity was 98.8% (559/566 control patients [95% CI 97.4 to 99.5]) in serum samples. Conclusions Although LFI may have limited sensitivity in serum, it can rapidly diagnose melioidosis in resource-limited settings.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85057205970&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/45933
ISSN: 18783503
00359203
Appears in Collections:Scopus 2018

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