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Title: Gametocyte Carriage, Antimalarial Use, and Drug Resistance in Cambodia, 2008-2014
Authors: Jessica T. Lin
Jaymin C. Patel
Lauren Levitz
Mariusz Wojnarski
Suwanna Chaorattanakawee
Panita Gosi
Nillawan Buathong
Soklyda Chann
Rekol Huy
Khengheng Thay
Darapiseth Sea
Nou Samon
Shannon Takala-Harrison
Mark Fukuda
Philip Smith
Michele Spring
David Saunders
Chanthap Lon
The University of North Carolina at Chapel Hill
University of North Carolina School of Medicine
Armed Forces Research Institute of Medical Sciences, Thailand
University of Maryland School of Medicine
Mahidol University
Armed Forces Research Institute of Medical Sciences
National Center for Parasitology, Entomology and Malaria Control
U.S. Army Medical Materiel Development Activity
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Nov-2018
Citation: The American journal of tropical medicine and hygiene. Vol.99, No.5 (2018), 1145-1149
Abstract: Gametocytes are the malaria parasite stages responsible for transmission from humans to mosquitoes. Gametocytemia often follows drug treatment, especially as therapies start to fail. We examined Plasmodium falciparum gametocyte carriage and drug resistance profiles among 824 persons with uncomplicated malaria in Cambodia to determine whether prevalent drug resistance and antimalarial use has led to a concentration of drug-resistant parasites among gametocyte carriers. Although report of prior antimalarial use increased from 2008 to 2014, the prevalence of study participants presenting with microscopic gametocyte carriage declined. Gametocytemia was more common in those reporting antimalarial use within the past year, and prior antimalarial use was correlated with higher IC50s to piperaquine and mefloquine, as well as to increased pfmdr1 copy number. However, there was no association between microscopic gametocyte carriage and parasite drug resistance. Thus, we found no evidence that the infectious reservoir, marked by those carrying gametocytes, is enriched with drug-resistant parasites.
ISSN: 14761645
Appears in Collections:Scopus 2018

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