Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: Genome polarity of RNA viruses reflects the different evolutionary pressures shaping codon usage
Authors: Supinya Phakaratsakul
Thanyaporn Sirihongthong
Chompunuch Boonarkart
Ornpreya Suptawiwat
Prasert Auewarakul
Faculty of Medicine, Siriraj Hospital, Mahidol University
Chulabhorn Royal Academy
Keywords: Immunology and Microbiology
Issue Date: 1-Oct-2018
Citation: Archives of Virology. Vol.163, No.10 (2018), 2883-2888
Abstract: © 2018, Springer-Verlag GmbH Austria, part of Springer Nature. RNA viruses are classified by their genome polarity and replication strategies. Nucleotide composition and codon usage differ among virus groups, for instance positive-sense RNA (+ssRNA) viruses have higher GC-content than the other RNA virus groups. Codon usage of +ssRNA viruses is closer to humans showing significantly higher codon adaptation index (CAI) than those of negative-sense RNA (-ssRNA), double stranded RNA (dsRNA) and retroviruses. Ambisense viruses have high CAI comparable to that of +ssRNA virus despite their lower GC content, whereas dsRNA viruses have the lowest CAI. This may provide a benefit for +ssRNA viruses as their genomes are used as mRNA. However, analyses for influence of nucleotide composition on codon usage did not show a difference between +ssRNA and –ssRNA viruses. This suggests that genome composition and hence mutational pressure remain the major pressure causing the differences in codon usage among RNA viruses with different genome types.
ISSN: 03048608
Appears in Collections:Scopus 2018

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.