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Title: Human monoclonal antibodies against West Nile virus from Japanese encephalitis-vaccinated volunteers
Authors: Tatsuhiko Ozawa
Hideyuki Masaki
Tomohiko Takasaki
Ikuko Aoyama
Takahiro Yumisashi
Atsushi Yamanaka
Eiji Konishi
Yoh Ohnuki
Atsushi Muraguchi
Hiroyuki Kishi
Osaka Prefectural Institute of Public Health
Osaka University
University of Toyama
Mahidol University
Kanagawa Prefectural Institute of Public Health
Kindai University
Keywords: Immunology and Microbiology;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jun-2018
Citation: Antiviral Research. Vol.154, (2018), 58-65
Abstract: © 2018 Elsevier B.V. West Nile virus (WNV) is a positive-sense single-stranded RNA flavivirus belonging to the Japanese encephalitis virus (JEV) serocomplex of the Flaviviridae family and causes mosquito-borne infections. Although most human infection cases are asymptomatic, approximately one in 150 infected individuals develops meningoencephalitis, with a mortality rate of 4–14%. While the development of human neutralizing antibody therapeutics against WNV is strongly anticipated, WNV is difficult to study in conventional laboratories due to its high safety level requirement. In this study, we established fully human WNV-neutralizing monoclonal antibodies from the peripheral blood mononuclear cells of inactivated-JEV-vaccinated individuals, and these antibodies exhibited WNV neutralization both in vitro and in vivo. Our results demonstrate a new antibody cross-reactivity strategy to develop immunological therapeutic reagents for WNV and other JEV serotype viruses.
ISSN: 18729096
Appears in Collections:Scopus 2018

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