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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/46022
Title: Plasmodium vivax and Plasmodium falciparum infection dynamics: Re-infections, recrudescences and relapses
Authors: Michael T. White
Stephan Karl
Cristian Koepfli
Rhea J. Longley
Natalie E. Hofmann
Rahel Wampfler
Ingrid Felger
Tom Smith
Wang Nguitragool
Jetsumon Sattabongkot
Leanne Robinson
Azra Ghani
Ivo Mueller
Instituto de Salud Global de Barcelona
Papua New Guinea Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Universitat Basel
Swiss Tropical and Public Health Institute (Swiss TPH)
Medical Research Council
Mahidol University
Institut Pasteur, Paris
Keywords: Immunology and Microbiology;Medicine
Issue Date: 17-Apr-2018
Citation: Malaria Journal. Vol.17, No.1 (2018)
Abstract: © 2018 The Author(s). Background: In malaria endemic populations, complex patterns of Plasmodium vivax and Plasmodium falciparum blood-stage infection dynamics may be observed. Genotyping samples from longitudinal cohort studies for merozoite surface protein (msp) variants increases the information available in the data, allowing multiple infecting parasite clones in a single individual to be identified. msp genotyped samples from two longitudinal cohorts in Papua New Guinea (PNG) and Thailand were analysed using a statistical model where the times of acquisition and clearance of each clone in every individual were estimated using a process of data augmentation. Results: For the populations analysed, the duration of blood-stage P. falciparum infection was estimated as 36 (95% Credible Interval (CrI): 29, 44) days in PNG, and 135 (95% CrI 94, 191) days in Thailand. Experiments on simulated data indicated that it was not possible to accurately estimate the duration of blood-stage P. vivax infections due to the lack of identifiability between a single blood-stage infection and multiple, sequential blood-stage infections caused by relapses. Despite this limitation, the method and data point towards short duration of blood-stage P. vivax infection with a lower bound of 24 days in PNG, and 29 days in Thailand. On an individual level, P. vivax recurrences cannot be definitively classified into re-infections, recrudescences or relapses, but a probabilistic relapse phenotype can be assigned to each P. vivax sample, allowing investigation of the association between epidemiological covariates and the incidence of relapses. Conclusion: The statistical model developed here provides a useful new tool for in-depth analysis of malaria data from longitudinal cohort studies, and future application to data sets with multi-locus genotyping will allow more detailed investigation of infection dynamics.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045539314&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/46022
ISSN: 14752875
Appears in Collections:Scopus 2018

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