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Title: Immunogenicity and safety of inactivated chromatographically purified Vero cell-derived Japanese encephalitis vaccine in Thai children
Authors: Pornthep Chanthavanich
Kriengsak Limkittikul
Chukiat Sirivichayakul
Watcharee Chokejindachai
Weerawan Hattasingh
Krisana Pengsaa
Surachai Surangsrirat
Termsang Srisuwannaporn
Benjawan Kaewma
Sutee Yoksan
Gao Jun
Bai Zhumu
Thailand Ministry of Public Health
Mahidol University
Liaoning Cheng Da Biotechnology Co., Ltd.
Keywords: Immunology and Microbiology;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 3-Apr-2018
Citation: Human Vaccines and Immunotherapeutics. Vol.14, No.4 (2018), 900-905
Abstract: © 2018 The Author(s). Published with license by Taylor & Francis © 2018, © Pornthep Chanthavanich, Kriengsak Limkittikul, Chukiat Sirivichayakul, Watcharee Chokejindachai, Weerawan Hattasingh, Krisana Pengsaa, Surachai Surangsrirat, Termsang Srisuwannaporn, Benjawan Kaewma, Sutee Yoksan, Gao Jun, and Bai Zhumu. Summary: Inactivated mouse-brain-derived Japanese encephalitis vaccine has a worrisome safety profile and the live attenuated vaccine is unsuitable in immunodeficiency. This study aimed to evaluate the immunogenicity and safety of an inactivated chromatographically purified Vero-cell-derived JE vaccine (CVI-JE, Beijing P-3 strain) in children. 152 healthy Thai children, with an average (SD) age of 14.4 (3.8) months, received 3 doses of CVI-JE on days 0, 7–28, and one year. Homologous JE neutralizing antibody titers (NT) were measured. All subjects had seroprotection [geometric mean titer (GMT) 150] 28 days' post 2nd vaccination. The seroprotection rates at 1 year after primary series and and 1 month after the booster were 89.3% (GMT 49) and 100% (GMT 621), respectively. Local and systemic reactions–fever (17.6%), vomiting (8%), and poor appetite (5.3%)–were noted within 28 days' post-vaccination. All these symptoms were self-limited. Conclusions: CVI-JE is safe, immunogenic, and provided high NT.
ISSN: 2164554X
Appears in Collections:Scopus 2018

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