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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/46038
Title: Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites
Authors: Sabine A. Fraschka
Michael Filarsky
Regina Hoo
Igor Niederwieser
Xue Yan Yam
Nicolas M.B. Brancucci
Franziska Mohring
Annals T. Mushunje
Ximei Huang
Peter R. Christensen
Francois Nosten
Zbynek Bozdech
Bruce Russell
Robert W. Moon
Matthias Marti
Peter R. Preiser
Richárd Bártfai
Till S. Voss
Harvard School of Public Health
London School of Hygiene & Tropical Medicine
Universitat Basel
Swiss Tropical and Public Health Institute (Swiss TPH)
University of Otago
Radboud University Nijmegen
Mahidol University
Nuffield Department of Clinical Medicine
Nanyang Technological University
University of Glasgow
Keywords: Immunology and Microbiology
Issue Date: 14-Mar-2018
Citation: Cell Host and Microbe. Vol.23, No.3 (2018), 407-420.e8
Abstract: © 2018 The Authors Heterochromatin-dependent gene silencing is central to the adaptation and survival of Plasmodium falciparum malaria parasites, allowing clonally variant gene expression during blood infection in humans. By assessing genome-wide heterochromatin protein 1 (HP1) occupancy, we present a comprehensive analysis of heterochromatin landscapes across different Plasmodium species, strains, and life cycle stages. Common targets of epigenetic silencing include fast-evolving multi-gene families encoding surface antigens and a small set of conserved HP1-associated genes with regulatory potential. Many P. falciparum heterochromatic genes are marked in a strain-specific manner, increasing the parasite's adaptive capacity. Whereas heterochromatin is strictly maintained during mitotic proliferation of asexual blood stage parasites, substantial heterochromatin reorganization occurs in differentiating gametocytes and appears crucial for the activation of key gametocyte-specific genes and adaptation of erythrocyte remodeling machinery. Collectively, these findings provide a catalog of heterochromatic genes and reveal conserved and specialized features of epigenetic control across the genus Plasmodium. Fraschka, Filarsky et al. performed a genome-wide characterization of heterochromatin organization across multiple species, strains, and life cycle stages of malaria parasites. This revealed that heterochromatic gene silencing is a conserved strategy to drive clonal variation of surface antigens and to control life cycle stage transitions and cell differentiation.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85043288655&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/46038
ISSN: 19346069
19313128
Appears in Collections:Scopus 2018

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