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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/46074
Title: Retrospective analysis of fever and sepsis patients from Cambodia reveals serological evidence of melioidosis
Authors: Vichaya Suttisunhakul
Phireak Hip
Pidor Ouch
Piseth Ly
Chonthida Supaprom
Agus Rachmat
Michael Prouty
Andrew Vaughn
Ahreej Eltayeb
Sim Kheng
Danielle V. Clark
James V. Lawler
Narisara Chantratita
Mary N. Burtnick
Paul J. Brett
Kevin L. Schully
Ministry of Health Cambodia
Mahidol University
University of Nevada School of Medicine
Naval Medical Research Center
Austere environments Consortium for Enhanced Sepsis Outcomes
U.S. Naval Medical Research Unit Two
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2018
Citation: American Journal of Tropical Medicine and Hygiene. Vol.98, No.4 (2018), 1039-1045
Abstract: © 2018 by The American Society of Tropical Medicine and Hygiene. Burkholderia pseudomallei, the etiologic agent of melioidosis, is predicted to be ubiquitous in tropical regions of the world with areas of highest endemicity throughout Southeast Asia (SEA). Nevertheless, the distribution of B. pseudomallei and the burden of melioidosis in many SEA countries remain unclear. In Cambodia, only two human endemic cases of melioidosis were reported through 2008 and since then only a few hundred cases have been described in the literature. This is in sharp contrast to the annual burden of thousands of cases in surrounding areas. To further investigate the prevalence of melioidosis in Cambodia, we used a recently developed O-polysaccharide-based rapid enzyme-linked immunosorbent assay to detect B. pseudomallei-specific antibodies in serum samples obtained from 1,316 febrile illness or sepsis patients from 10 different provinces. Based on a cutoff value derived through cultureconfirmed melioidosis cases, the proportion of positive samples in our cohort was approximately 12%. Regression analysis indicated that the odds of obtaining a positive result were 2.2 times higher for males than females controlling for age and province (95% confidence interval: 1.6-3.2,P< 0.001). Consistent with this, 9.2% of females were positive versus 18.2% of males (P < 0.001). Notably, 22.5% of grain or rice farmers were positive versus 10.1% of subjects with occupations not involving regular contact with soil. Positive results varied significantly by province. Collectively, the results of this study suggest that the true burden of melioidosis in Cambodia is greater than has previously been reported.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045424462&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/46074
ISSN: 00029637
Appears in Collections:Scopus 2018

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