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Title: Nonalcoholic fatty liver disease and urolithiasis. A systematic review and meta-analysis
Authors: Karn Wijarnpreecha
Susan Lou
Panadeekarn Panjawatanan
Anawin Sanguankeo
Surakit Pungpapong
Frank J. Lukens
Patompong Ungprasert
University of Minnesota Twin Cities
Faculty of Medicine, Siriraj Hospital, Mahidol University
Mayo Clinic in Jacksonville, Florida
The Johns Hopkins School of Medicine
Chiang Mai University
Bassett Medical Center
Keywords: Medicine
Issue Date: 1-Dec-2018
Citation: Journal of Gastrointestinal and Liver Diseases. Vol.27, No.4 (2018), 427-432
Abstract: © 2018, Romanian Society of Gastroenterology. All rights reserved. Background & Aims: Recent studies have suggested that nonalcoholic fatty liver disease (NAFLD) could be a predisposing factor for urolithiasis but the results have been inconsistent. This systematic review and meta-analysis was conducted with the aim to summarize all available data. Methods: A comprehensive literature review was conducted using MEDLINE and EMBASE databases through March 2018 to identify all studies that compared the risk of urolithiasis among patients with NAFLD versus those without NAFLD. Effect estimates from each study were extracted and combined together using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: A total of eight studies with 238,400 participants fulfilled the eligibility criteria and were included in the meta-analysis. The risk of urolithiasis among patients with NAFLD was significantly higher than in those without NAFLD with a pooled odds ratio of 1.81 (95% confidence interval, 1.29-2.56; I2 92%). Conclusions: A significantly increased risk of urolithiasis among patients with NAFLD was observed in this meta-analysis.
ISSN: 18418724
Appears in Collections:Scopus 2018

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