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Title: Association Between Juxtapapillary Duodenal Diverticula and Risk of Choledocholithiasis: a Systematic Review and Meta-analysis
Authors: Karn Wijarnpreecha
Panadeekarn Panjawatanan
Wuttiporn Manatsathit
Wisit Cheungpasitporn
Surakit Pungpapong
Frank J. Lukens
Patompong Ungprasert
University of Nebraska Medical Center
Faculty of Medicine, Siriraj Hospital, Mahidol University
University of Mississippi Medical Center
Mayo Clinic in Jacksonville, Florida
Chiang Mai University
Bassett Medical Center
Keywords: Medicine
Issue Date: 1-Dec-2018
Citation: Journal of Gastrointestinal Surgery. Vol.22, No.12 (2018), 2167-2176
Abstract: © 2018, The Society for Surgery of the Alimentary Tract. Background/Objectives: Studies have suggested that the presence of juxtapapillary duodenal diverticula (JDD) could be a predisposing factor for choledocholithiasis. This systematic review and meta-analysis was conducted with the aims to summarize all available evidence to better characterize the risk. Methods: A literature search was performed using MEDLINE and EMBASE database from inception to January 2018. Cross-sectional studies that reported odd ratios (OR) comparing the risk of choledocholithiasis among individuals with JDD versus individuals without JDD were included. Pooled OR and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. Results: Of 527 retrieved articles, 11 studies met our eligibility criteria and were included in analysis. We found a significant association between the presence of JDD and choledocholithiasis with the pooled OR of 2.30 (95% CI, 1.84–2.86). The statistical heterogeneity was moderate with an I 2 of 60%. Conclusions: A significantly increased risk of choledocholithiasis among individuals with JDD was observed in this study.
ISSN: 1091255X
Appears in Collections:Scopus 2018

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